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Bladder instillations for Bladder Pain / Interstitial Cystitis


Cystistat® is sodium hyaluronate. It helps to replenish the natural protective coating of the bladder (the glycosaminoglycan (GAG) layer), which is deficient in many patients with BPS / interstitial cystitis. Some studies have shown that Cystistat can reduce bladder discomfort and the frequency of urination.

Cystistat® is instilled directly into the bladder using a catheter. This is often done in the outpatient clinic by your specialist, but some patients can learn to administer this treatment themselves. An initial course of four treatments are given over four weeks. Additional treatments may be required in some patients before any response is seen. After this, additional treatments can be given as required - usually every 6 to 12 weeks.

Cystistat® is only usually prescribed by a specialist.


Uracyst is chondroitin, which is one of the components of the protective "GAG layer" in the bladder. It is given in the same way as Cystistat (see above) and repeated treatments can be given to patients who respond well.


DMSO treatment aims to reduce pain and inflammation and some studies have suggested an improvement in up to 70% of cases.

Like Cystistat, DMSO is instilled into the bladder through a catheter and held inside for about 15 minutes. Three or four treatments are given every two weeks. Some patients find the treatment uncomfortable and there may be burning or stinging passing urine afterwards. Because DMSO is absorbed and excreted though the lungs, some patients notice a garlic-like taste and odour for a day or two.

If some improvement is found the treatments can be repeated when necessary.